Step Use: It is an intermediate for dyes, pigents, pharmaceuticals Paracetamol, Phenacetin etc. Chemicals: Acetanilide. Glacial acetic acid. HNO 3. Apparatus: Conical flask.
Glass rod. Buchner funnel. Step 1: Preparation of p-Nitroacetanilide from Acetanilide. Add dry acetanilide 25 g to glacial acetic acid 25 ml in a beaker and then introduce concentrated sulphuric acid 50 ml slowly with constant stirring to obtain clear solution. Place the beaker in a freezing mixture of ice and salt to cool the solution below 5 o C.
Add a cold mixture of concentrated nitric acid 11 ml and concentrated sulphuric acid 7 ml drop wise with constant stirring to a reaction mixture while maintaining the temperature below 5 o C. After adding all the mixed acid, remove the beaker from the freezing mixture and keep it for 1 hr at room temperature. Pour the reaction mixture into an ice cold water 30 ml to obtain the crude product of p- nitroacetanilide.
Filter it on suction, wash with cold water till free from acid and recrystallize the pale yellow product from ethanol to get colourless crystalline solid, m. Note: o -Nitroacetanilide remains in the filtrate due to its high solubility in water. Step 2: Preparation of p—Nitroaniline from p-Nitroacetanilide. Reflux the mixture for min. Wash it thoroughly with water. Recrystallize the product using a mixture of equal volume of rectified sprit and water or from hot water.
Here limiting reagent is acetanilide; hence yield should be calculated from its amount. Theoretical yield:. Therefore, 25 g acetanilide will form …….? X g p-nitroaniline. Step 1: preparation of p-aminobenzoic acid from p-nitrobenzoic acid Step 2: preparation of Salicylic acid interacts with acetic When an acid containing the —COOH group reacts Production of alcohol from sugarcane Punit Tripathi. Bacterial growth curve cultivation of anaerobs Suman Kumar Mekap.
We Labmonk, some scientific researchers unite to design a platform for getting sources of different lab protocols and discuss various research related issues. All rights reserved. To separate p-nitroacetanilide from this mixture, the reaction mixture is recrystallised in ethanol, so that the more readily soluble o-nitroacetanilide dissolves in ethanol and pure p-nitroacetanilide separates out.
It is mainly used for dyeing textiles. It contains the characteristic group. Azo compounds have an extended conjugated system and are often coloured and are used as dyes.
These compounds are prepared by the reaction known as coupling reaction. Nitrous acid is produced in the reaction mixture by the reaction of sodium nitrite with hydrochloric acid. The procession of conversion of aromatic primary amines into diazonium salt is known as diazotisation.
This benzene diazonium compound undergoes a coupling reaction with 2-Naphthol to form 2-Naphyhol aniline dye. Cite this Simulator:. Preparation of Organic Compounds. Objectives Our objectives are to prepare: A sample of acetanilide from aniline.
A sample of dibenzal acetone. A sample of p-nitro acetanilide from acetanilide. A sample of 2-naphthol aniline dye. The Theory What is Organic Chemistry? Which was the first organic compound to be synthesised in the lab and by whom? What is organic synthesis? Synthesis of some simple organic compounds. Acetanilide Acetanilide is prepared from aniline by acetylating it with acetic anhydride in the presence of glacial acetic acid. Dibenzal acetone It is prepared from benzaldehyde and acetone by Claisen-Schmidt Reaction.
The chemical reaction is represented as follows; 3. Learning Outcomes Students understand the concepts of organic compounds, classification of organic compounds, functional groups, substitution, addition, elimination and rearrangement reactions. Students acquire the skills to prepare: Acetanilide Dibenzal acetone p-Nitro acetanilide 2-Naphthol aniline dye Students understand the chemicals required for the preparation of the above compounds.
Students understand the theory behind the formation of acetanilide, dibenzal acetone, p-Nitro acetanilide and 2-Naphthol aniline dye. Once they understand the different steps, students can perform the experiment in the real lab more accurately and quicker.
Students understand important safety precautions before using hazardous chemicals. Cite this Simulator: www.
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